Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve

Jing Wang; Xinyao Pan; Jing Zhou; Xin Li; Yan Sun; Ling Wang

doi:10.5582/ddt.2022.01109

Review

Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve

Jing Wang, Xinyao Pan, Jing Zhou, Xin Li, Yan Sun, Ling Wang

Author information

Jing Wang
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Xinyao Pan
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Jing Zhou
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Xin Li
Urumqi hospital of traditional Chinese medicine, Urumqi, Xinjiang, China.
Yan Sun
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Ling Wang
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.

Keywords: dehydroepiandrosterone, diminished ovarian reserve, testosterone, in vitro fertilization and embryo transfer

JOURNAL FREE ACCESS

2023 Volume 17 Issue 2 Pages 87-94

DOI https://doi.org/10.5582/ddt.2022.01109

Browse “Advance online publication” version

Details

Abstract

Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted. Therefore, we summarize the mechanisms and indications of DHEA for DOR.

Corresponding author

Register with J-STAGE for free!