Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
Original Articles
Ferulic acid induces heme oxygenase-1 via activation of ERK and Nrf2
Zengchun MaQian HongYuguang WangQiande LiangHongling TanChengrong XiaoXianglin TangShuai ShaoSisi ZhouYue Gao
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2011 Volume 5 Issue 6 Pages 299-305

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Abstract

This study investigated the effect of ferulic acid (FA) on the up-regulation of heme oxygenase-1 (HO-1) in lymphocytes and the molecular mechanisms involved. Lymphocytes were treated with FA (0.001-0.1 μM) for certain times. Cell viability, the activity and level of expression of HO-1, and signal pathways were analyzed. FA significantly up-regulated HO-1 expression both at the level of mRNA and protein in lymphocytes. Moreover, FA-induced NF-E2-related factor (Nrf2) nuclear translocation and transcriptional activity, which is upstream of FAinduced HO-1 expression. In addition, lymphocytes treated with FA exhibited activation of extracellular regulated kinase (ERK) and treatments with U0126 (an ERK kinase inhibitor) attenuated the FA-induced activation of Nrf2, resulting in a decrease in HO-1 expression. Zinc protoporphyrin (ZnPP, a HO-1 inhibitor) markedly suppressed cytoprotection from radiation-induced cell damage by FA. Results suggested that the ERK signaling pathway controlled the anti-oxidation of FA by regulating the expression of the antioxidant enzyme HO-1.

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© 2011 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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