Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Brief Report
Synthesis and anticancer activity of novel 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles
Peng WangJianzhen LiuHualu XingYang LiuWencheng XieGuisen Zhao
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2012 Volume 6 Issue 3 Pages 133-139

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Abstract

A new series of 5-(indole-2-yl)-3- substituted 1,2,4-oxadiazoles were synthesized and evaluated for their anticancer activities. Structures of the compounds were confirmed by spectroscopic methods. Structural modifications were done to improve the antiproliferative activity of compound 1. The results indicated that a benzyloxyl substituent on the C-4 position was better than a methyl substituent on the C-6 position of the indole component. Compounds 10a, 10b, 10g, 10i, 10l, 10n, 10o, and 10p were found to be more active than lead compound 1 in the PC-3 cell line. These compounds may serve as lead candidates in the development of novel chemotherapeutics for cancer treatment.

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© 2012 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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