Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Original Articles
Antioxidant and hepatoprotective activity of an ethanol extract of Syzygium jambos (L.) leaves
Md. Rafikul IslamMst. Shahnaj ParvinMd. Ekramul Islam
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JOURNALS FREE ACCESS

2012 Volume 6 Issue 4 Pages 205-211

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Abstract

Herbal medicines have traditionally been used worldwide for the prevention and treatment of liver disease with fewer adverse effects. The leaves of the Syzygium jambos (SJL) plant were chosen and studied for their antioxidant activity in vitro and hepatoprotective activity in vivo. The antioxidant activity of the ethanol extract was examined in vitro using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, reducing capacity, total phenol, total flavonoid content, and total antioxidant capacity. The extract had significant dose-dependent antioxidant activity in all in vitro experiments. IC50 values of SJL and ascorbic acid (standard) were found to be 14.10 and 4.87 μg/mL, respectively, according to a DPPH radical scavenging assay. Hepatoprotective activity of the plant extract was evaluated in a rat model of carbon tetrachloride (CCl4)-induced liver damage. CCl4 significantly altered serum marker enzymes, total bilirubin, total protein, and liver weight. The extract caused these values to return to normal in rats with CCl4-induced liver damage that were given SJL. This indicated the hepatoprotective potential of SJL and was comparable to use of the standard drug silymarin. Thus, the present study revealed that SJL may have antioxidant and hepatoprotective activity.

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© 2012 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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