Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Reviews
Derivatization in liquid chromatography for mass spectrometric detection
Tomofumi Santa
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2013 Volume 7 Issue 1 Pages 9-17

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Abstract

Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) has been frequently utilized for the sensitive and selective determination of the trace level compounds in biological samples. In LC/ESI-MS/MS, chemical derivatization is sometimes used to enhance the detection sensitivity of the analytes. This review presents an overview of the derivatization reagents in LC/ESI-MS/MS that have been applied to the low molecular weight compounds in recent five years (2008-2012).

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© 2013 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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