Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Original Articles
Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide
Fangyuan ShiZongtao LiLingjin KongYuanchao XieTao ZhangWenfang Xu
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2014 Volume 8 Issue 3 Pages 117-120


As a RNA polymerase inhibitor, 6-fluoro-3-hydroxypyrazine-2-carboxamide commercially named favipiravir has been proved to have potent inhibitory activity against RNA viruses in vitro and in vivo. A four-step synthesis of the compound is described in this article, amidation, nitrification, reduction and fluorination with an overall yield of about 8%. In addition, we reported the crystal structure of the title compound. The molecule is almost planar and the intramolecular O−H•••O hydrogen bond makes a 6-member ring. In the crystal, molecules are packing governed by both hydrogen bonds and stacking interactions.

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© 2014 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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