Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Original Articles
In vitro and in vivo anti-MRSA activities of nosokomycins
Ryuji UchidaHideaki HanakiHidenori MatsuiHiroshi HamamotoKazuhisa SekimizuMasato IwatsukiYong Pil KimHiroshi Tomoda
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2014 Volume 8 Issue 6 Pages 249-254

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Abstract

The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.

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© 2014 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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