In vitro and in vivo anti-MRSA activities of nosokomycins

Ryuji Uchida; Hideaki Hanaki; Hidenori Matsui; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masato Iwatsuki; Yong Pil Kim; Hiroshi Tomoda

doi:10.5582/ddt.2014.01050

Original Articles

In vitro and in vivo anti-MRSA activities of nosokomycins

Ryuji Uchida, Hideaki Hanaki, Hidenori Matsui, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masato Iwatsuki, Yong Pil Kim, Hiroshi Tomoda

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Keywords: Nosokomycins, silkworm infection assay, anti-MRSA antibiotic, Streptomyces cyslabdanicus K04-0144, therapeutic efficacy

JOURNAL FREE ACCESS

2014 Volume 8 Issue 6 Pages 249-254

DOI https://doi.org/10.5582/ddt.2014.01050

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Abstract

The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.

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