Subcellular localization of KL-6 mucin in intraductal papillary mucinous neoplasm of the pancreas

Yoshinori Inagaki; Yasuji Seyama; Kiyoshi Hasegawa; Wei Tang; Norihiro Kokudo

doi:10.5582/ddt.2014.01027

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Subcellular localization of KL-6 mucin in intraductal papillary mucinous neoplasm of the pancreas

Yoshinori Inagaki, Yasuji Seyama, Kiyoshi Hasegawa, Wei Tang, Norihiro Kokudo

著者情報

キーワード: KL-6 mucin, intraductal papillary mucinous neoplasm, invasion

ジャーナルフリー早期公開

論文ID: 2014.01027

DOI https://doi.org/10.5582/ddt.2014.01027

この記事には本公開記事があります。

The final version of this article is now available: Vol. 8 (2014), No. 4 pp. 173-177

詳細

抄録

This study aimed to clarify the expression profile of KL-6 mucin in intraductal papillary mucinous neoplasm (IPMN) and its relation to tumor malignancy. Expression of KL-6 mucin in 38 IPMNs (intraductal papillary mucinous adenoma (IPMA), 24 cases; minimally invasive intraductal papillary mucinous carcinoma (MI-IPMC), 8 cases; invasive carcinoma originating from IPMC (IC-IPMC), 6 cases) and 66 pancreatic ductal adenocarcinomas (PDACs) was evaluated immunohistochemically. IC-IPMCs and MI-IPMCs had positive staining of KL-6 mucin whereas 58% of IPMAs tested negative. Subcellular localization of KL-6 mucin varied among IPMNs whereas all of the PDAC had positive expression in the circumferential membrane and cytoplasm of cancer cells. IC-IPMCs and MI-IPMCs had a higher frequency of circumferential membrane and cytoplasmic localization of KL-6 mucin than did IPMAs. These results suggest that localization of KL-6 mucin could be used to predict the malignancy of IPMN.

責任著者(Corresponding author)

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