Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831

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Regulation of food intake and the development of anti-obesity drugs
Yue Chen
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JOURNAL FREE ACCESS Advance online publication

Article ID: 2016.01014


As the most significant cause of death worldwide, obesity has become one of the world's most important public health problems, but approved anti-obesity drugs are extremely limited. This article summarizes the feeding control circuits and regulators involved in obesity development, highlight the hypothalamus, melanocortin system and brain-gut peptide actions in this process, and the five US FDA approved anti-obesity medications in long term use, namely phentermine/topiramate, lorcaserin, naltrexone/bupropion, liraglutide and orlistat.

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© 2016 International Research and Cooperation Association for Bio & Socio-Sciences Advancement