A Search for Backseat Players in Regulation of Differentiation and Function of Cells Constituting Hard Tissues —Phagocyte-type NADPH Oxidase, Monocarboxylate Transporter-1, and Lysine Gingipain—

Yoichi MIYAMOTO

doi:10.7881/dentalmedres.33.51

平成24年度上條奨学賞（研究業績部門）受賞

A Search for Backseat Players in Regulation of Differentiation and Function of Cells Constituting Hard Tissues

—Phagocyte-type NADPH Oxidase, Monocarboxylate Transporter-1, and Lysine Gingipain—

Yoichi MIYAMOTO

著者情報

キーワード: chondrocytes, osteoclasts, NADPH oxidase-2, monocarboxylate transporter-1, lysine gingipain

ジャーナルフリー

2013 年 33 巻 1 号 p. 51-55

DOI https://doi.org/10.7881/dentalmedres.33.51

J-STAGE : dentalmedres 33 3 pp.374-374

詳細

抄録

Since joining Showa University, I have been studying the regulatory mechanisms related to differentiation and functions of hard-tissue-constituting cells. Here I present two topics that have recently received out attention. The first is monocarboxylate transporter-1, a molecule involved in cellular energy metabolism, which controls the expression of phagocyte-type NADPH oxidase and cell death in chondrocytes. The other is lysine gingipain, a protease produced by Porphyromonas gingivalis that promotes osteoclast differentiation.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）