Abstract
Angiosarcoma is known to be one of the most fatal sarcomas. It frequently metastases to the lung and may become fatal there. Although a standard chemotherapy for angiosarcoma is still not established, the combination chemotherapy with CYVADIC regimen (cyclophosphamide, vincristine, doxorubicin, dacarbazine) is widely accepted. This regimen showed a high response ratio in some early trials, but later trials raised doubts about its effects. Moreover, the CYVADIC regimen frequently causes serious bone marrow suppression, and it put aged cases at high risk. Recently, some authors reported the cases of angiosarcoma successfully treated with a new anti-tumor agent, taxanes. We herein report a case of breast angiosarcoma with multiple metastases in the lung treated with weekly docetaxel (taxotere®) therapy. A complete response was observed after two courses of therapy. This case maintains complete remission for five months as of February 2003.
