Abstract
A 38 year-old woman who had been suffering from epilepsy since 1977 has been treated with sodium valproate 1,000 mg daily for the most recent seven years. In April of 2001, she had a convulsive episode, so carbamazepine was added to her medication at that time. On June 5th, she suddenly had a high fever, pruritic skin rash, and leukocytosis with eosinophilia (27%). The biopsy specimen revealed features resembling those of drug-related eruptions. DLSTs for carbamazepine and sodium valproate were negative. On patch testing, carbamazepine induced a positive reaction and the same pruritic skin rash over the area tested. We diagnosed this case as drug-related eruption due to carbamazepine and flare caused by patch testing. This was a rare case of flare from patch testing with carbamazepine.
