2003 Volume 113 Issue 7 Pages 1087-1093
We present an outline of the cutaneous wound healing cascade, emphasizing the importance of the interaction between regenerated keratinocytes and fibroblasts via cAMP during the proliferative stage of wound healing. We suggest that this mechanism can be explained by the cycle theory. In addition, we speculate that vasculogenesis might contribute to the vascular development of granulation tissues, as well as to angiogenesis. In clinical practice, we stress that the choice of treatment should be adapted to the wound stage. Finally, it should be kept in mind that contact dermatitis due to disinfectants and ointments used in refractory ulcers is possible.