Abstract
A case of 27-year-old woman with NF1 was tried to treat her small fleckling on the trunk with either photo RF irradiation and/or topical vitamin D3 (maxacalcitol) ointment. The fleckling area of her abdomen was divided into four parts ; 1) photo RF+vitamin D3, 2) photo RF only, 3) vitamin D3 only, 4) no treatment. The most effective therapeutic modality was found to be the combination therapy. Histopathological findings of the treated pigment spot clearly showed decrease in melanin pigment on the basal layer and also decrease in melanophages in the upper dermis. L* value of the L*a*b*system of the colorimeter was increased in the treated area, which means that the treated area got lightening from darker appearance. These results indicate that this combination therapy is effective and safe in the tratment of small fleckling of NF1, and this modality can be a new option for the treatment of pigmented lesions of NF1.
