Abstract
A 52 year-old woman developed purple maculars and nodules on the left forearm with chronic lymphedema at the age of 38 years right after radical mastectomy of breast cancer. A skin biopsy specimen showed angiosarcoma. The tumor lesions were recurred locally in the grafted skin a few days after the local excision. Magnetic resonance imaging (MRI) showed metastatic lesions in the left upper arm. The patient was treated with systemic chemotherapy with mesna, doxorubicin, ifosfamide, and dacarbazine (MAID regimen). Partial remission of the lesion on the forearm was observed after three cycles of MAID every four weeks. The major side effect of this treatment was only bone marrow suppression, while microscopic hematuria due to ifosfamide was not observed. Our present case suggests that this combination chemotherapy is effective for advanced progressive angiosarcoma.
