2006 Volume 116 Issue 4 Pages 455-460
A case of systemic lupus erythematosus（SLE) presented with reddish-brown macules on her buttock of 22 years duration. She had been treated for SLE with oral predonisolone. Histological examination of the macule showed sclerotic cells in the dermis, and fungal culture showed chromomycosis. The macules improved with the treatment of intravenous fluconazole infusion. An ulcer with necrotic tissue was found on the her left dorsal side of hand. Histological examination showed yeast-like cells in the entire dermis. Fungal culture showed cryptococcosis. The ulcer improved with the treatment of intravenous fluconazole infusion. This case showed decreased CD4 positive lymphocytes and decreased IgG in her peripheral blood. These findings indicated that the decreased immune response led to the complication of chromomycosis and cryptococcosis for SLE.
