皮膚疾患患者に対するステロイド内服治療が骨密度及び体組成に及ぼす影響

岸本 正実; 谷岡 未樹; 荒川 明子; 松村 由美; 中村 元信; 是枝 哲; 松吉 徳久; 高橋 健造; 桒原 晶子; 小川 蓉子; 木戸 詔子; 田中 清; 宮地 良樹

doi:10.14924/dermatol.118.1253

Original Articles

The Effects of Oral Glucocorticoid Therapy on Bone Mineral Density and Body Composition in Dermatologic Patients

Masami Kishimoto, Miki Tanioka, Akiko Arakawa, Yumi Matsumura, Motonobu Nakamura, Satoshi Kore-eda, Norihisa Matsuyoshi, Kenzo Takahashi, Syoko Kuwabara, Yoko Ogawa, Syoko Kido, Kiyoshi Tanaka, Yoshiki Miyachi

Author information

Masami Kishimoto
Department of Food and Nutrition, Kyoto Women’s University
Miki Tanioka
Department of Dermatology, Graduate School of Medicine, Kyoto University
Akiko Arakawa
Department of Dermatology, Graduate School of Medicine, Kyoto University
Yumi Matsumura
Department of Dermatology, Graduate School of Medicine, Kyoto University
Motonobu Nakamura
Department of Dermatology, Graduate School of Medicine, Kyoto University
Satoshi Kore-eda
Department of Dermatology, Graduate School of Medicine, Kyoto University
Norihisa Matsuyoshi
Department of Dermatology, Graduate School of Medicine, Kyoto University
Kenzo Takahashi
Department of Dermatology, Graduate School of Medicine, Kyoto University
Syoko Kuwabara
Department of Food and Nutrition, Kyoto Women’s University
Yoko Ogawa
Department of Food and Nutrition, Kyoto Women’s University
Syoko Kido
Department of Food and Nutrition, Kyoto Women’s University
Kiyoshi Tanaka
Department of Food and Nutrition, Kyoto Women’s University
Yoshiki Miyachi
Department of Dermatology, Graduate School of Medicine, Kyoto University

Keywords: glucocorticoid, bone mineral density, body composition

JOURNAL RESTRICTED ACCESS

2008 Volume 118 Issue 7 Pages 1253-1259

DOI https://doi.org/10.14924/dermatol.118.1253

Details

Abstract

Bone mineral density (BMD) and body composition were examined using a cross-sectional study of patients undergoing glucocorticoid treatment at the Dermatology Clinic of Kyoto University Hospital. The BMD of the radius was significantly lower than that of the age-matched population. In addition, the changes in the BMD of the lumbar spine paralleled the average daily dosage of glucocorticoid. We found no correlation between parameters reflecting the body composition and the cumulative or average daily dosage of glucocorticoid. However, in one case available for long-term follow-up, the effects of corticosteroid on muscle loss and fat gain were evident. It appears that the changes of muscle and fat tissue, which have more rapid metabolisms than bone, were not detected by this cross-sectional study.

Corresponding author

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