Abstract
We performed a clinicopathological study of granular cell tumor (GCT) by reexamining the clinical data from 73 cases (74 lesions). The study included 23 male and 50 female patients. The average age at resection time was 45.4 years. The tumors were mostly located on the trunk (40%). No case had been clinically diagnosed as GCT; dermatofibroma was the most frequent clinical diagnosis. We examined the histological findings in 29 lesions. Epidermal hyperplasia was present in 74% (17/23 lesions), including 3 lesions with pseudoepitheliomatous hyperplasia. Nodular lymphocytic inflammatory infiltrates were seen in 28% (8/29 lesions). Small peripheral nerves surrounded by granular cells and intranuclear pseudo-inclusion bodies were observed respectively in 48% (14/29 lesions) and 83% (24/29 lesions). These findings support the hypothesis that GCT is a neural tumor.
