2020 Volume 130 Issue 12 Pages 2567-2571
Case 1: A 35-year-old man who had been treated for five years with prednisolone and cyclosporin for eosinophilia developed purpura and edema suddenly in his legs without any trigger. Case 2: A 36-year-old woman developed purpura suddenly in her left leg and left ankle joint, also without a trigger. In both cases, a prolongation of activated partial thromboplastin time (APTT), a decrease in Factor VIII (FVIII) activity, and an elevated activity of FVIII inhibitors were contributing factors. The patients were diagnosed with acquired hemophilia A and treated with systemic prednisolone. After treatment, the titer of FVIII inhibitors became negative. Because acquired hemophilia A can be lethal due to unexpected bleeding, it is important to consider this disease when treating cases of extensive, sudden eccymosis without trigger.
