The Contributions of Objectively Measured Physical Activity, Sedentary Behavior, and Sleep to Successful Weight Loss Maintenance

Abstract

A novel flexible biosensor for the lactate detection based on organic thin-film transistors (OTFTs) is demonstrated. Because lactate is well known as a biomarker for assessing physical performance of human body, flexible (and wearable) lactate sensors could contribute the monitoring of human health conditions. The designed OTFT for the flexible biosensor device can be fabricated on a plastic substrate, and it is operated under low-voltage. The flexible OTFT shows stable electric-characteristics. In addition, the fabricated OTFT possesses an extended-gate electrode modified with layers of a lactate oxidase, a horseradish peroxidase, and an osmium-redox polymer for lactate detection in aqueous media, meaning that the continuous measurement of lactate levels has been successfully demonstrated. We believe that insight obtained opens up opportunities for applying OTFTs in wearable and flexible biosensor devices.