The Role of Proteasome System of Skeletal Muscle in Endurance Exercise

Abstract

Ubiquitin-proteasome system is known as a major proteolysis in skeletal muscle. Previous studies suggested that proteasome is important to homeostasis of skeletal muscle. However, the role of proteasome during exercise has not been elucidated yet. Therefore, in this study, we aimed to elucidate the role of proteasome in skeletal muscle during endurance exercise, and hypothesized that skeletal muscle specific proteasome gene knock out mice have lower ability of endurance exercise than control mice.As a result of endurance exercise test, skeletal muscle-specific proteasome gene knock out mice showed significant decrease in running time compared with control mice. These findings suggested that proteasome in skeletal muscle might contribute to endurance exercise. The role of proteasome during endurance exercise needs to be further examined.