Training and Exercise Effect on The Kidney Diseases

Abstract

Chronic kidney disease is a serious health problem, and the effectiveness of exercise and training as prevention and treatment has not been fully verified particularly in terms of basic molecular biology and physiology. In this study, we employed a mouse model in which albuminuria induced by a high-fat diet is reduced by treadmill exercise as previously reported. We performed RNA sequencing combined with cluster enrichment analysis of mouse renal tissue with different diets and training programs, and found a group of genes related to inflammatory responses and stress responses that were upregulated by a high-fat diet and then downregulated by exercise. These genes include Cxcl2, which encodes chemoattractive chemokines which mainly affect neutrophils in inflammatory response. Therefore, we focus on their physiological effects and then performed immunohistological evaluation of neutrophil infiltration in kidney tissues obtained from mice with high fat diet and/or exercise. However, unfortunately, no changes in cellular infiltration were observed in response to a high-fat diet or exercise. This does not deny other biological of the chemokine effect than we anticipated. Indeed, in chronic inflammation, the role of neutrophils is less well understood and has been described as either beneficial or detrimental, causing tissue damage and enhancing the immune response. Based on the results of this comprehensive study, we intend to further elucidate the renal receptor mechanisms associated with exercise and aim to provide basic scientific insights into the effects of training and exercise in chronic kidney disease.