Abstract
In recent years, AI has become easier to use, and applied research using AI has been progressing rapidly. In this paper, we report on the details of the development of a card game that leads to an understanding of acid-base neutralization reactions, based on a proposal we made with science and engineering students after designing a learning game in chemistry through dialogue with an AI. The establishment of the development process in collaboration with AI is expected to contribute to the diffusion and promotion of educational and learning games in school education, etc.