2022 年 1 巻 1 号 p. 4-13
In the process of repair from tissue injury, 'regeneration' naturally occurs in-vivo. Also in the vessels, mechanical stress induces injury, but then the injured sites are repaired by tissue regeneration. Our research has long focused on stem cell biology in vascular injury and repair. In the process of repair from vascular injury, bone marrow-derived stem cells including endothelial progenitor cells (EPCs) are recruited, and the EPCs differentiate into endothelial cells, leading to endothelial regeneration. On the other hand, also in the cardiovascular scene, regenerative medicine has been clinically applied as vascular and myocardial regeneration. We have been promoting vascular regeneration therapy (angiogenesis therapy) for critical limb ischemia, using adipose-derived regenerative (stem) cells (ADRCs). Now, we are planning a new project for research and clinical application of regenerative medicine, using the multi-lineage differentiating stress enduring (Muse) cell as a novel cell source.
