Drug Metabolism and Pharmacokinetics
Online ISSN : 1880-0920
Print ISSN : 1347-4367
ISSN-L : 1347-4367
Reviews
Polymorphic Transporters and Platinum Pharmacodynamics
Jason A. SPROWLRachel A. NESSAlex SPARREBOOM
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JOURNAL FREE ACCESS

2013 Volume 28 Issue 1 Pages 19-27

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Abstract

  Several solute carriers and ATP-binding cassette transporters have been implicated in the influx or efflux of platinum-based chemotherapeutic agents such as cisplatin, carboplatin, and oxaliplatin. Given that many of these proteins are highly polymorphic, the genetic status of these proteins could be an important contributor to the extensive interindividual pharmacokinetic variability associated with the clinical use of these agents. In this review article, we provide an updated overview of the various transporters that have shown promise in animal models or patient populations in facilitating the movement of platinum-based agents across cell membranes, and how their function is associated with drug disposition or pharmacodynamic effects.

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© 2013 by The Japanese Society for the Study of Xenobiotics
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