リポソーム封入抗癌剤の抗腫瘍効果に関する速度論的研究：シュミレーションスタディーによる最適な薬物放出速度の予測：

抄録

In this study, we constructed the physiological model linked with cell kill kinetic model via the concentration of antitumor drugs in extracellular space. We studied the antitumor effect of liposomal antitumor drugs with alteration on uptake rate constant of liposomes by reticuloendothelial system and release rate constant of drug from liposomes. This simulation study was performed to clarify the relationship between antitumor effect and pharmacokinetic or physicochemical parameters of liposomes as well as pharmacological or physiological parameters of tumor tissues. Thus, we attempted to estimate the antitumor effect of liposomal antitumor drugs quantitatively with the tumor cells numbers. The existence of optimum release rate of each liposomal doxorubicin and vincristine was indicated constantly in this study.