Abstract
To estimate quantitative information of antitumor effect, simulations were performed by the physiological model linked with a cell kill kinetic model. Antitumor effect of liposomal DOX was increased with the increase of blood circulating time. There was the optimum rate of drug release (krel) from long circulating liposomes. To examine this model, we prepared liposomes with different krel, which can be made by changing lipid composition such as HEPC, EPC and CHO. Antitumor effect of liposomal DOX with different krel was evaluated by survival experiments. Liposomes with the lowest krel showed the highest antitumor effect. This result was different from our predicitori based on the computer simulations, which regured some corrections of our model.
