Abstract
In cancer therapy, intratumoral injection is an effective way to maximize the action of injected substances at the tumor site, however there is little information on the disposition characteristics of the injected materials after intratumoral injection. To clarify the effect of molecular size and surface charge of various drugs and carriers in the tumor at an organ level, their pharmacokinetic properties after intratumoral injection were studied in the perfusion experiments employing the tissue-isolated tumor preparation. Pharmacokinetic analysis of their venous outflow patterns revealed that alteration of the physicochemical properties of drugs and carriers dominantly changed the rate of transfer from the poorly-perfused region to the well-perfused region, suggesting that this process is the determinant factor which alters the intratumoral behavior of drugs and carriers after direct injection.
