Abstract
Bermoprofen, 2-(8-methyl-10, 11-dihydro-11-oxodibenz (b, f) oxepin-2-yl) propionic acid, is a potent non-steroidal antipyretic agent. Metabolism of bermoprofen in man was studied after oral administration by gas chromatography-mass spectrometry. The results were as follows:
1. Three metabolites were identified together with the unchanged drug in human plasma, a 11-hydroxy metabolite (M 1), a 8-carboxy-11-hydroxy metabolite (M2) and a 8-carboxy metabolite (M 3).
2. In urine, the glucuronic acid conjugates of bermoprofen and M 1 were also detected together with the above metabolites.
3. The major metabolic pathway of bermoprofen in man was found to be the reduction of the carbonyl group at 11 position, followed by the conjugation with glucuronic acid, which was similar to that in monkey.
