抄録
There is increasing evidence demonstrating time-dependent changes in effectiveness and toxicity of several agents. Recently we investigated some chronopharmacological aspects of antihypertensive agents such as diuretic, adrenoceptor blocking and calcium channel blocking. We observed that the effects of diuretic agent are greater when it is administered at the rest period than when it is administered during the active phase. On the contrary, the effectiveness as well as toxicity of adrenoceptor and calcium channel blocking agents are greater following administration at the active period. In this minireview, the chronopharmacolgical profiles of antihypertensive agents are summarized in detail.
