Placental transfer and milk transfer of ¹⁴C-benidipine·HCl

Abstract

¹⁴C-Benidipine·HCl (KW-3049) was administered orally at a dose level of 1mg/kg to pregnant (12 and 19 th day of gestation) Wistar rats. The tissue localization of the radioactivity was visualized by whole body autoradiography or measured after dissection. The radioactivity level in the fetus was less than one-third of that in the maternal plasma and disappeared rapidly. Radioactivity level in the fetal brain was higher than that in the maternal brain. ¹⁴C-KW-3049 was also administered orally at a dose level of 1 mg/kg to lactating Wistar rats (14 th day after delivery). The concentrations of radioactivity in the milk were almost same as that in the maternal plasma.