Abstract
Absorption, distribution and excretion of 14C-benidipine•HCl(KW-3049) were studied in monkeys after oral administration (1.0mg/kg).
1. Plasma levels reached the maximum of 157.7±129.5ng equiv./ml at 3.7±3.8hr after oral administration and decreased with the half-life of 93.6±33.7 hr at the terminal elimination phase.
2. The radioactivity extensively distributed to the tissues after oral administration. Relatively high radioactivity was found in the liver, kidney and prostate. The radioactivity in most tissues decreased proportionally to that in plasma.
3. The radioactivity excreted in urine and feces within 120hr after oral administration was 20.9±5.2% and 76.1±7.0% of dose, respectively.
