抄録
As physiological and anatomical factors affecting intestinal drug absorption, unidirectional water flow, solvent drag, absorptive site blood flow and electrophysiological parameters such as membrane resistance and capacitance were examined. Effects of some absorption enhancers on the two absorption pathways, the transcellular and paracellular pathways, were also examined from the alteration of the above factors. One of the effective enhancers, sodium caprate (C10), increased the following absorption parameters for the paracellular pathways : (i) the equivalent pore radius which was obtained by the water absorption ; (ii) the permeabilities of water-soluble nonelectrolytes and ionic drugs ; (iii) junctional resistance and basolateral membrane capacitance which were obtained by impedance analysis. The C10 effects on the trancellular pathway were found in the membrane perturbation which was obtained by fluorescence polarization. For the action mechanism of C10 in the paracellular pathways, the C10 effect on the physiological regulation of membrane, stimulation of C10 to contraction of perijunctional actomyosin ring, is now under investigation.
