The effect of food intake on the bioavailability of vamicamide, a new anticholinergic drug, was studied in six healthy male volunteers. Each subject, in a two-way crossover manner, was given a single 18-mg oral dose of vamicamide after overnight fasting or 30 minutes after a standard breakfast. There were no significant differences in the area under the serum concentration-time curve, the maximum serum concentration, the time to reach the maximum serum concentration, elimination half-life, renal clearance or urinary recovery between the fasting and non-fasting state. These results showed that the bioavailability of vamicamide appears to be little affected in the presence of food.
