Abstract
For basic studies on vaccination protocol in dogs, the levels of antibodies produced by canine parvovirus vaccien (CPV) and canine distemper vaccine (CDV) were measured in clinically healthy dogs that had received the mixed vaccine of these every year or every three years. In hemagglutination inhibition antibody titers of CPV, there was a statistically significant difference between the every-year group and the every-three-year group. Antibody titers of over 64, which are considered sufficiently protective against the infection, were detected in all 17 dogs injected every year, and in 14 of 18 dogs injected every three years. On the other hand, as to CDV neutralization antibody, there was no significant difference between the two groups. Antibody levels of over 64 were found in 16 out of 17 dogs vaccinated every year, and in 11 out of 18 dogs of the other group. The data suggested that annual vaccination with these mixed vaccines is necessary from a preventive medicine point of view.
