Abstract
The efficacy and safety of a difluprednate ophthalmic solution 0.05% were evaluated clinically against canine uveitis. This drug was administered to 33 cases, 26 cases were available for evaluation, and cases that did not meet our criteria were omitted. Efficacy was evaluated as remarkable in 20 cases (76.9%), as good in five cases (19.2%), and as unchanged in only one case (3.8%). Namely, the cumulative curative rate was extremely high (96.2%). To check for side effects, intraocular pressure was measured in each case. Intraocular pressure was 10.1 ± 3.8 mmHg (mean ± standard deviation) before the start of the topical instillation. On day 7 ± 2, the pressure was 12.8 ± 2.9 mmHg, and on day 14 ± 3, the pressure was 14.4 ± 9.4 mmHg, which indicated significant increases, but were still normal values. There were two adverse cases: one case with irritation at the time of topical instillation, and the other with abnormally increased intraocular pressure. Consequently, remarkable efficacy against canine uveitis of a 0.05% difluprednate ophthalmic solution was shown, although attention should be paid to intraocular pressure.
