Efficacy and Safety of 0.3 % Lomefloxacin Solution for the Treatment of Bacterial Otitis Externa in Dogs

Abstract

In this study, we evaluated the efficacy and safety of 0.3 % lomefloxacin solution for eyes and ears, in treating dogs clinically diagnosed as suffering bacterial otitis externa. To check the efficacy of the lomefloxacin solution, 110 dogs were used. The treatment was ‘markedly effective’ in 60.0%, and ‘markedly effective’ and ‘effective’ in 90.9% of them. Only 9.1% remained ‘unchanged’. Total scores of symptoms before and after treatment were significantly different. To check the safety of the drug, 151 dogs were used. It was judged to be ‘safe’ in 94.7%, ‘slightly suspicious’ in 4.6%, and ‘suspicious’ in 0.7%. Eleven adverse symptoms were observed in 10 dogs: 3 symptoms (vomiting, redness of the auricle, and substituted microbism) in 3 dogs were judged to have no causal relationship with the drug. The remaining 8 adverse symptoms (substituted microbism in 7 dogs, and irritation of the ear in 1 dog) were judged to be side effects of the drug, although they were not serious. From these results, the drug was considered to be effective in treating bacterial otitis externa.