In this study, we evaluated the efficacy and safety of 0.3 % lomefloxacin solution for eyes and ears, in treating dogs clinically diagnosed as suffering bacterial otitis externa. To check the efficacy of the lomefloxacin solution, 110 dogs were used. The treatment was ‘markedly effective’ in 60.0%, and ‘markedly effective’ and ‘effective’ in 90.9% of them. Only 9.1% remained ‘unchanged’. Total scores of symptoms before and after treatment were significantly different. To check the safety of the drug, 151 dogs were used. It was judged to be ‘safe’ in 94.7%, ‘slightly suspicious’ in 4.6%, and ‘suspicious’ in 0.7%. Eleven adverse symptoms were observed in 10 dogs: 3 symptoms (vomiting, redness of the auricle, and substituted microbism) in 3 dogs were judged to have no causal relationship with the drug. The remaining 8 adverse symptoms (substituted microbism in 7 dogs, and irritation of the ear in 1 dog) were judged to be side effects of the drug, although they were not serious. From these results, the drug was considered to be effective in treating bacterial otitis externa.
A two-month-old male mixed-breed cat was brought to us with a history of lameness. Radiographically, a generalized decrease in bone opacity and fractures of the right distal femur and proximal tibia were found. A serum biochemical profile revealed low ionized calcium and markedly high parathormone concentration. The cat had been fed a diet mainly composed of chicken meat. Treatment consisting of external fixation, cage confinement, and a diet of commercial kitten food resulted in a quick recovery. This case was diagnosed as nutritional secondary hyperparathyroidism, on the basis of the clinical, radiographic, and biochemical findings, and also the content of the cat’s daily meal. The quick recovery by dietary modification proved that the diagnosis was correct.
A spayed 10-year-old American shorthair cat with repeated wheezing was suspected to have asthma. Serum antigen specific IgE test showed that the cat was slightly positive against pollen allergens of Lolium perenne and Fascue meadow. Eosinophil counts were high in both the peripheral blood and the bronchoalveolar lavage fluid. A provocation test was performed using pollen/grass allergen mixture (seven grasses including Lolium perenne and Fascue meadow.), double-blind-wise and randomly, and the asthmatic cause was confirmed. Therefore, rush intranasal hyposensitization therapy was performed using this allergen mixture. Six months after the hyposensitization was started, the clinical condition of the cat became stable. In this case, there was a correlation (r = 0.74) between the percentage of eosinophile in the peripheral blood and the frequency of asthmatic attacks.
A six-year-old female American shorthair cat with weight loss and lymphadenopathy was referred to our hospital. Ultrasonography revealed the presence of enlarged mesenteric lymph nodes, and thickened small intestine wall with no ultrasonographic layering structure in it. Large granular lymphocyte (LGL) lymphoma was diagnosed by fine needle biopsy of the mesenteric lymph node. The cat was treated with combination chemotherapy focusing on L-asparaginase, and survived until the 424th day. This is a rare case of feline LGL lymphoma with 15-month survival, maintaining good quality of life.