2017 Volume 26 Issue 1 Pages 10-15
In this study, we investigated the symptoms and changes in serum creatinine concentrations that occurred in healthy adult cats being fed a diet of squid．We found that the cats vomited and the serum creatinine concentrations measured with the DRI－CHEM 7000V（DRI－CHEM）increased; however, the concentrations measured by the quinone dye method，which is reported to be more accurate，were within normal limits．We also investigated the symptoms and changes in serum creatinine concentrations that occurred in healthy adult dogs being fed a diet of squid．The dogs did not vomit but did develop increased serum creatinine concentrations. With DRI－CHEM, we analyzed small molecular weight amines using ion chromatography and confirmed that the serum dimethylamine（DMA）concentrations were increased in both cats and dogs being fed a diet of squid．Therefore，we assumed that DMA was the causative agent that influenced the creatinine concentrations measured with DRI-CHEM．The cause of increased serum DMA concentrations in cats and dogs being fed a diet of squid seems to be the large quantities of DMA contained in squid
