In this study, we investigated the symptoms and changes in serum creatinine concentrations that occurred in healthy adult cats being fed a diet of squid．We found that the cats vomited and the serum creatinine concentrations measured with the DRI－CHEM 7000V（DRI－CHEM）increased; however, the concentrations measured by the quinone dye method，which is reported to be more accurate，were within normal limits．We also investigated the symptoms and changes in serum creatinine concentrations that occurred in healthy adult dogs being fed a diet of squid．The dogs did not vomit but did develop increased serum creatinine concentrations. With DRI－CHEM, we analyzed small molecular weight amines using ion chromatography and confirmed that the serum dimethylamine（DMA）concentrations were increased in both cats and dogs being fed a diet of squid．Therefore，we assumed that DMA was the causative agent that influenced the creatinine concentrations measured with DRI-CHEM．The cause of increased serum DMA concentrations in cats and dogs being fed a diet of squid seems to be the large quantities of DMA contained in squid
Twenty-two dogs diagnosed with canine heartworm disease (HWD) were classified into four groups (Class 1 [11 dogs], Class 2 [5 dogs], Class 3 [5 dogs], and Class 4 [1 dog]). Treatment was attempted with oral doxycycline and ivermectin combined with a single injection of melarsomine. The mean survival time until the final observation day was 504 days [22 dogs], and the mortality was 22.7% ([5/22 dogs]: Class 1 [1/11 dogs], Class 3 [4/5 dogs]). The mean time to negative conversion on the antigen test before the final observation day was 312 days, and the negative conversion rate was 95% (19 of the 20 dogs tested were negative) . Furthermore, in Class 3 dogs, the ascites disappeared for 76 days in 1 dog and for 685 days in another dog, and the disappearance of ascites and significant improvement in fainting spells were observed for 812 days in 1 dog. Moreover, improvement in the findings of the chest X-ray examination and significant improvement in the clinical symptoms were confirmed in 1 dog in Class 4. Our results indicate that treatment with oral doxycycline and ivermectin combined with a single injection of melarsomine is safe and can be effectively used for the treatment of canine HWD.
We found a cyst in the right kidney of an 11-year-old castrated miniature dachshund. We suspected the symptoms as simple renal cyst by cytodiagnosis of the cyst puncture liquid and imagiintensityng examination. We examined the cyst wall in detail using thin MIP(maximum/minimum intensity projection) image by contrast-enchanced CT and we could not completely deny the malignant tumor. Therefore, we resected the cyst wall by surgery. Histopathologically, the cyst wall was diagnosed as renal cell carcinoma. In this case, we had hard time to distinguish renal cell carcinoma from simple renal cyst in various examination.
An approximately 11-year-old neutered female Shih Tzu was admitted to the hospital with the primary complaint of collapse after coughing. Holter electrocardiography was performed, which confirmed sinus arrest coinciding with the episode of coughing. In addition, as the owner was filming a video of the dog's state at the time of the episode, the series of events could be observed, which facilitated the diagnosis of the present case as “situational syncope caused by cough”.
The gallbladder was temporarily drained using a percutaneous endoscopic gastrostomy (PEG) feeding tube in three dogs and two cats with extrahepatic biliary tract obstruction. Their general conditions were extremely poor. In all cases, there was an immediate decrease in the total bilirubin and liver enzyme values that were elevated preoperatively. Since the general condition of four animals improved, cholecystectomies were performed at later dates and their prognosis had become favorable. In the remaining case, despite a rapid decline in the levels of total bilirubin and liver enzyme values after surgery, there was no improvement in the general condition, and the animal eventually died. This method has various advantages, such as being relatively less invasive, since it does not approach the duodenal side, and allows for the regular and effective removal of bile. It also had limitations, such as the need for two surgeries, including the removal of the drain for permanent treatment and home management. If these can be offset, this method may show potential as a permanent cure or for the management of extrahepatic biliary tract obstruction.
Histological and immunohistochemical examination of a feline hepatic neoplasm was conducted. A Japanese domestic neutered female cat, 5 years and 6 months old, 4.8kg in weight, and suffering from anorexia, depression, and vomiting was evaluated. The presence of a tumor in the right lateral lobe of the liver was revealed by an ultrasound examination and elevated liver enzymes on the blood examination. A suspected neoplasm was subsequently surgically removed. The mass was located in the lateral right hepatic lobe and was solid, dark reddish, rich in blood, and 3.5 × 2.5 × 2.0 cm in size. Microscopic examination revealed the cord and ductal structure of the neoplasm cells. Grimelius staining revealed positive granules in the cytoplasm, particularly concentrated toward the inside of the duct. Based on these findings, the tumor was diagnosed as a hepatic carcinoid, which is rare in cats. Immunohistochemical analysis showed that the tumor cells were positive for cytokeratin AE1/3, S100 protein, and NSE and negative for chromogranin A. It was suggested that feline carcinoids were not reactive with the chromogranin A antibody, which is broadly used as the marker for neuroendocrine tumors.