Isolation and metabolites analysis of actinomycetes from deep-sea water in Toyama Bay

Abstract

Various bioactive compounds have been discovered from actinomycetes; however, it is difficult to obtain a new compound in recent years. Therefore, a new group of actinomycetes is required which has a different potential for secondary metabolite production. In this study, we report the isolation and metabolites of actinomycetes in Toyama Bay. The results of genus-level identification, 110 actinomycetes isolates were identified as Streptomyces (88 strains), Micromonospora (19strains), Actinomadura (2 strains), and Nocardiopsis (1 strain). The metabolite analysis by the HPLC-UV spectra database showed that 41％ of strains produced unknown UV compounds. The selected strain produced 5 new compounds. These results indicated that deep-sea water is a useful isolation source of actinomycetes for drug discovery.