2002 Volume 3 Issue 2 Pages 71-76
Hyaluronidase inhibitory effect was found in the water extract of a diatom species, Navicula directa (W. Smith) Ralfs (N. directa) isolated from deep sea water (DSW) of Toyama Bay. Hyaluronidase inhibitory effect (IC50: 28 μg/ml) of ethanol insoluble fraction from the water extract was 4 times stronger than that (IC50: 110 μg/ml) of a current anti-allergic agent, disodium cromoglycate (DSCG). Ethanol insoluble fraction was very thermostable and showed a wide range of pH stability. On the basis of these data, ethanol insoluble fraction seemed to be useful for the treatment of allergic diseases, such as atopic dermatitis and pollinosis.
