Long-term efficacy and safety of lamotrigine: Results from the open-label extension of the lamotrigine monotherapy study in adult Japanese patients with epilepsy

Abstract

To investigate the efficacy and safety of long-term lamotrigine monotherapy, 22 Japanese patients (19 with newly diagnosed epilepsy and 3 with recurrent epilepsy) were enrolled in the extension phase of the study after completion of 30 weeks of lamotrigine treatment. More than 80% of patients remaining at each time point achieved seizure-free status at all time points up to week 120 in the extension phase. No unexpected adverse events were reported. Our findings suggest that long-term lamotrigine monotherapy appears to be effective and generally well tolerated in adult Japanese patients with partial seizures and generalized tonic-clonic seizures.