Abstract
HSP100/Clp family of proteins, unnoticed until quite recently, involves in various cellular activities in the various cellular locations in the living organisms. Their family proteins have been classified into subfamilies based upon their sequence similarities. Their functions are varied, e.g. to obtain the tolerance to the higher temperature, to enhance the proteolytic activity by the protease, to promote transport, and so on. It seems that even the proteins in the same subfamily in the different organisms have the different features. However, HSP100/Clp proteins have one feature in common, playing a role as a molecular chaperone utilizing ATP to accomplish these activities.
