Abstract
Rat serum complement was mesured during the course of hepatoma induction by D. A. B. in the different protein intake. The animal consists of a group of rats feeded by high protein diet (protein content 26%) and another group of rats fed by moderate protein diet (protein content 13%) containg 0.005% D. A. B..
Serum complement was mesured 2, 4, and 6 months (8 months for high protein diet group) after the onset of D. A. B. feeding. All the rats were sacrificed 6 months after D. A. B. feeding and the high protein diet group 8 months after and the liver and spleen were studied.
In the high protein group the serum complement dropped 4 months after D. A. B. feeding whic gradually elevated from 6th to 8th month but still to be lower than the control group. On 8 hht month after D. A. B. feeding none of the rats developed hepatoma, which the spleen showed non remarkable follicular atrophy.
In the moderate protein feeding group the serum complement dropped 2 months faster tha of the high protein feeding group and Hepatoma develop much heavier and became malignant at a faster rate than that of the high protein feeding group.
