Insulin Resistance-related Gray Matter Volume Reduction is Associated with          the Default Mode Network

SAKI ASANO; AKITOSHI OGAWA; TAKAHIRO OSADA; SATOSHI OKA; KOJI NAKAJIMA; YASUSHI OSHIMA; SAKAE TANAKA; HIDEYOSHI KAGA; YOSHIFUMI TAMURA; HIROTAKA WATADA; RYUZO KAWAMORI; SEIKI KONISHI

doi:10.14789/ejmj.JMJ24-0044-OT

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Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network

SAKI ASANO, AKITOSHI OGAWA , TAKAHIRO OSADA, SATOSHI OKA, KOJI NAKAJIMA, YASUSHI OSHIMA, SAKAE TANAKA, HIDEYOSHI KAGA, YOSHIFUMI TAMURA, HIROTAKA WATADA, RYUZO KAWAMORI, SEIKI KONISHI

Author information

SAKI ASANO
Department of Neurophysiology, Juntendo University School of Medicine [Japan]
AKITOSHI OGAWA Corresponding author
Department of Neurophysiology, Juntendo University School of Medicine [Japan]
TAKAHIRO OSADA
Department of Neurophysiology, Juntendo University School of Medicine [Japan]
SATOSHI OKA
Department of Neurophysiology, Juntendo University School of Medicine [Japan]
KOJI NAKAJIMA
Department of Neurophysiology, Juntendo University School of Medicine [Japan]
Department of Orthopaedic Surgery, The University of Tokyo School of Medicine [Japan]
YASUSHI OSHIMA
Department of Orthopaedic Surgery, The University of Tokyo School of Medicine [Japan]
SAKAE TANAKA
Department of Orthopaedic Surgery, The University of Tokyo School of Medicine [Japan]
HIDEYOSHI KAGA
Department of Metabolism and Endocrinology, Juntendo University School of Medicine [Japan]
Sportology Center, Juntendo University School of Medicine [Japan]
YOSHIFUMI TAMURA
Department of Metabolism and Endocrinology, Juntendo University School of Medicine [Japan]
Sportology Center, Juntendo University School of Medicine [Japan]
HIROTAKA WATADA
Department of Metabolism and Endocrinology, Juntendo University School of Medicine [Japan]
Sportology Center, Juntendo University School of Medicine [Japan]
RYUZO KAWAMORI
Department of Metabolism and Endocrinology, Juntendo University School of Medicine [Japan]
Sportology Center, Juntendo University School of Medicine [Japan]
SEIKI KONISHI Corresponding author
Department of Neurophysiology, Juntendo University School of Medicine [Japan]
Sportology Center, Juntendo University School of Medicine [Japan]
Research Institute for Diseases of Old Age, Juntendo University School of Medicine [Japan]
Advanced Research Institute for Health Science, Juntendo University School of Medicine [Japan]

Keywords: voxel-based morphometry, homeostatic model assessment for insulin resistance, functional connectivity, hypothalamus

JOURNAL OPEN ACCESS

2025 Volume 71 Issue 1 Pages 32-35

DOI https://doi.org/10.14789/ejmj.JMJ24-0044-OT

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Abstract

In this study, we observed that insulin resistance is linked to a reduction in grey matter volume in the default-mode and limbic networks of the cerebral cortex in older adults. Additionally, we found that the paraventricular nucleus of the hypothalamus is significantly functionally connected to these two cortical networks. Our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus.

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