3b06 Anticancer activity of some mesogenic compounds possessing a crown ether moiety against A549 human lung cancer cell line

Abstract

We prepared some crown ether derivatives possessing phenylpyrimidine or cyanobiphenyl as a mesogenic unit. Those compounds were tested against A549 human lung cancer cell line. They were found to show marked suppression of cell proliferation. The cell cycle analysis indicates that the crown ether derivatives induce cell death in the tumor cell. Furthermore, we investigated effects of mesogenic structure on the anticancer activity. The phenylpyrimidine derivatives induced necroptosis, while the cyanobiphenyl derivatives induced necrosis.