Electro-reductive Halogen-Deuterium Exchange and Methylation of Aryl Halides in Acetonitrile

Koichi MITSUDO; Takahiro OKADA; Shuichi SHIMOHARA; Hiroki MANDAI; Seiji SUGA

doi:10.5796/electrochemistry.81.362

Communications

Electro-reductive Halogen-Deuterium Exchange and Methylation of Aryl Halides in Acetonitrile

Koichi MITSUDO, Takahiro OKADA, Shuichi SHIMOHARA, Hiroki MANDAI, Seiji SUGA

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Keywords: Electro-reduction, Halogen-Deuterium Exchange, Deuteriation, Methylation

JOURNAL FREE ACCESS

2013 Volume 81 Issue 5 Pages 362-364

DOI https://doi.org/10.5796/electrochemistry.81.362

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Abstract

An electro-reductive halogen-deuterium exchange reaction in CD₃CN has been developed. Using 9-fluorenone as a mediator, the electro-reduction of several aryl halides proceeded smoothly to give the deuterated products selectively. A methylation reaction of aryl halides also proceeded under similar conditions.

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