Electrochemistry
Online ISSN : 2186-2451
Print ISSN : 1344-3542
Communications
ATP-mediated Release of a DNA-binding Protein from a Silicon Nanoneedle Array
Daisuke MATSUMOTOMaui NISHIOYoshio KATOWataru YOSHIDAKoichi ABEKyoko FUKAZAWAKazuhiko ISHIHARAFutoshi IWATAKazunori IKEBUKUROChikashi NAKAMURA
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JOURNALS OPEN ACCESS

2016 Volume 84 Issue 5 Pages 305-307

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Abstract

We describe a new method for delivering a zinc finger protein directly into cells using a nanoneedle array and an ATP aptamer. The zinc finger protein can be used for site-specific DNA modification by combining with an enzyme that can cut or modify DNA. This controlled release method utilizes aptamer conformational changes to deliver various biomolecules specifically into cells.

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© 2016 The Electrochemical Society of Japan
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